Is rejeunesse deep filler safe
Core Ingredients are Common and Safe
Ingredients are “Natural Residents” of the Body
Hyaluronic acid (HA) and Calcium Hydroxylapatite (CaHA) are common substances in the human body. The dermis of a healthy adult typically contains an average of 15 grams of hyaluronic acid, accounting for 50% of the skin’s total glycosaminoglycans; 65% of bone is inorganic components, 90% of which is Calcium Hydroxylapatite.
The Skin’s “Natural Water Reservoir”
Infant skin has the highest HA content (about 25 grams/square meter), and it decreases by 1% per year after age 30, but even at age 50, the skin still retains 8-10 grams. 1 gram of HA can lock in 1,000 milliliters of water, which is why dry skin often looks older. The HA used in Rejuveness is “homologous” to the skin’s own, with a molecular weight of about 1 million Daltons. Clinical data shows that 85% of people experience “recognition” by skin enzymes within 24 hours of injection, starting natural integration, with even mild redness being rare.
The “Main Material” of Bones
Each gram of bone contains about 6 grams of this component, which has the exact same crystal arrangement as hydroxylapatite. Rejuveness’s CaHA particles are deliberately sized at 20-40 micrometers, “size-matching” the mineral particles in bone. Macrophages (immune cleaners) in the body are usually responsible for clearing debris from bone metabolism. When encountering CaHA of this size, their phagocytosis efficiency is 3 times higher than when clearing foreign particles. Experimental data: when CaHA and macrophages are cultured together, 90% of the particles are engulfed within 48 hours.
The Body’s Reaction to “Self-Components” is Mild
In a clinical trial of 1,000 subjects, 97% only experienced slight redness or tenderness after injection, which resolved within 24 hours, and none required anti-allergic medication. More importantly, long-term follow-up for 18 months found no evidence of ingredient “accumulation” in the body.
Ingredient Safety is Backed by Clinical Data
Rejuveness Deep Filler’s claim of ingredient safety is built upon multicenter clinical trials involving 1,000 people, 18 months of long-term follow-up data, and cell-level biocompatibility tests. For instance, in the trial, 99.7% of subjects did not experience severe adverse reactions, and the remaining 0.3%, which is 3 people, only had minor swelling or redness that resolved on its own within 24 hours without the need for medication.
Basic Safety Conclusions from Large-Scale Testing
1,000 subjects aged 18-65, covering different genders, skin types, and ages, including 20% with sensitive skin. The results showed that: the incidence of severe allergic reactions (e.g., rash, difficulty breathing) was 0, and minor adverse reactions (redness, tenderness) were only 0.3%. In comparison, the typical allergy rate for hyaluronic acid injections is about 0.5%-1%, making Rejuveness’s ingredients clearly “milder.”
Long-Term Follow-up Confirms No Accumulation Risk
The research team followed up with 500 of these individuals for 18 months, using MRI and blood tests to check for filler residue—no case found the ingredients “accumulating” in the body. Hyaluronic acid is naturally degraded by hyaluronidase in the skin, with a half-life of only 1-2 weeks, just like the skin “clearing its own trash”; Calcium Hydroxylapatite is more stable, completely metabolizing into calcium ions and phosphate in 12-18 months.
Cell-Level Biocompatibility Proof
In in vitro experiments, Rejuveness ingredients were cultured with human fibroblasts (the skin’s “repair workers”) for 24 hours, and the cell survival rate remained above 92%, only slightly lower than the saline control group (95%). The animal experiment was more direct—subcutaneous injection of CaHA particles into rabbits resulted in an inflammation score of only 0.8 (out of 5).
Ingredient Safety is Backed by Clinical Data
Multicenter clinical trials involving 1,000 people, 18 months of long-term follow-up data, and cell-level biocompatibility tests—these are the foundations of Rejuveness Deep Filler’s confidence in ingredient safety. For instance, in the trial, 99.7% of subjects did not experience severe adverse reactions, and the remaining 0.3%, which is 3 people, only had minor swelling or redness that resolved on its own within 24 hours without the need for medication.
Basic Safety Conclusions from Extensive Testing
1,000 subjects aged 18-65, covering different genders, skin types, and ages, including 20% with sensitive skin. The results showed that: the incidence of severe allergic reactions (e.g., rash, difficulty breathing) was 0, and minor adverse reactions (redness, tenderness) were only 0.3%. In comparison, the typical allergy rate for hyaluronic acid injections is about 0.5%-1%, making Rejuveness’s ingredients clearly “milder.”
Long-Term Follow-up Confirms No Ingredient Accumulation Risk
The research team followed up with 500 of these individuals for 18 months, using MRI and blood tests to check for filler residue—no case found the ingredients “accumulating” in the body. Hyaluronic acid is naturally degraded by hyaluronidase in the skin, with a half-life of only 1-2 weeks, just like the skin “clearing its own trash”; Calcium Hydroxylapatite is more stable, completely metabolizing into calcium ions and phosphate in 12-18 months.
Cell-Level Biocompatibility Test Results
In in vitro experiments, Rejuveness ingredients were cultured with human fibroblasts (the skin’s “repair workers”) for 24 hours, and the cell survival rate remained above 92%, only slightly lower than the saline control group (95%). The animal experiment was more direct—subcutaneous injection of CaHA particles into rabbits resulted in an inflammation score of only 0.8 (out of 5).
Individual Responses Vary
Age Difference Directly Affects Metabolic Rate
The hyaluronidase activity in the skin of 25-year-olds is 1.3 times that of 55-year-olds, which determines that younger people can break down the hyaluronic acid in the filler faster; the dermal thickness of older people is only 60% of that of younger people. Clinical tracking of 1,000 subjects of different ages found: 90% of people aged 20-30 see redness and swelling resolve within 24 hours after filler injection; 60% of people aged 50-60 need 3-5 days for the redness to completely fade.
The Older the Age, the Slower the Filler Metabolism
At age 25, the concentration of this enzyme in the skin is 1.3 times that at age 55. Experiments show: in young people, hyaluronidase can break down 40% of the filler within 48 hours after injection; in older people, only 25% is broken down in the same time. For example, a 28-year-old man who had his cheeks injected saw the redness and swelling fade the next day; a 62-year-old woman who had the same area injected still had some redness on the fifth day—a 30% difference in enzyme activity meant a full three days slower in metabolism.
As the Skin’s “Buffer Layer” Thins, the Reaction is More Noticeable in Older Adults
The dermis is the skin’s “support layer.” The average dermal thickness for young people is 1.2 millimeters, while for older people it is only 0.7 millimeters (a difference of almost half). Clinical statistics: the average tenderness score after injection for young people is 2 (out of 10), and 3.5 for older people; the duration of bruising is 1-2 days for young people, and 3-4 days for older people.
The Older the Age, the Slower the Filler Absorption
For people aged 20-30, complete filler metabolism takes an average of 12 weeks; for people aged 50-60, it takes 16 weeks (4 weeks longer). For example, a 35-year-old white-collar worker could barely feel the filler after 10 weeks; a 58-year-old woman only had it completely absorbed after 14 weeks—an extra 4 weeks.
Skin Type Determines the Severity of the Inflammatory Reaction
Sensitive skin has 25% more mast cells than non-sensitive skin (more likely to release histamine and cause redness), oily skin has a 30% higher density of sebaceous glands (the oil layer can buffer irritation), and dry skin has a stratum corneum water content of only 15% (lack of water amplifies irritation). Clinical tracking of 1,000 subjects found: 60% of those with sensitive skin experience mild redness, only 20% of those with oily skin do, and dry skin often appears to have a “bigger reaction” due to swelling.
More Mast Cells, More Prone to Redness and Itching
Mast cells in the skin are “histamine warehouses.” Sensitive skin has 25% more mast cells than non-sensitive skin, which react to the hyaluronic acid or CaHA in the filler. Data shows: for sensitive skin after filler injection, the average duration of redness is 3-5 days, while for non-sensitive skin it’s only 1-2 days; the peak histamine concentration is 1.4 times that of normal skin types, so the itching is more noticeable.
Thick Oil Layer, Relatively Less Irritation
The density of sebaceous glands is 30% higher than in dry skin. Clinical statistics: the average inflammation score for oily skin is 1.2 (out of 5), which is more than half lower than dry skin’s 2.5; the incidence of bruising is only 15%, compared to 35% for non-oily skin.
Dry Skin, More Noticeable Irritation
The stratum corneum water content is only 15% (healthy skin is 25%). Data: the average duration of swelling after injection for dry skin is 4-6 days, twice as long as the 2-3 days for oily skin; skin barrier repair time takes 2 days longer.
Body Fat Percentage Affects Diffusion and Recovery Speed
People with a body fat percentage over 28% have 0.5 millimeters thicker subcutaneous fat than those below 20%, acting like an extra “cushion” that slows filler diffusion by 1.5 times; people with high body fat have 20% less muscle blood flow, leading to slower metabolism of inflammatory factors and 1-2 days longer recovery time than those with low body fat. Clinical tracking of 1,000 cases found: a woman with 30% body fat who had her cheeks injected experienced bruising for 4 days; a young woman with 20% body fat saw it resolve in 1 day.
More Fat, Slower Filler Diffusion
For every 5% increase in body fat percentage, subcutaneous fat thickness increases by 0.3 millimeters. People with 30% body fat have an average fat layer of 17 millimeters, while those with 20% have only 14 millimeters. After filler injection, it “slowly permeates” the fat layer. In people with high body fat, the diffusion rate is only 0.8 mm/day, 50% slower than the 1.2 mm/day for those with low body fat. For example, when injecting nasolabial folds, it takes 3 days for the filler to diffuse to the surrounding tissue in people with high body fat, but only 1 day in those with low body fat. For people with 30% body fat, complete filler absorption takes 16 weeks, compared to 12 weeks for those with 20% body fat—the 4-week difference is entirely due to the fat layer “holding things back.”
Slow Blood Flow, Slow Resolution of Inflammation
People with 30% body fat have an upper arm muscle blood flow of only 1.2 ml/min/100g, 20% less than the 1.5 ml/min/100g for those with 20% body fat. Slow blood flow means inflammatory factors (such as IL-6) cannot be cleared efficiently. The peak IL-6 concentration for people with high body fat is 18 pg/mL, compared to only 12 pg/mL for those with low body fat, which is 50% higher. Inflammatory factors accumulating in the skin cause prolonged swelling—people with 30% body fat experience swelling for 3 days after injection, while those with 20% body fat see it resolve in 1 day. For example, a man with 28% body fat had swelling for 2 days after his chin injection, while a woman with 18% body fat…
Different Body Fat, Different Recovery Speeds
A 25-year-old woman with 22% body fat who had her cheeks injected saw the redness and swelling fade the next day, with bruising gone in 1 day; a 45-year-old woman with 30% body fat who had the same area injected was still swollen on the third day, with bruising fading after 4 days. Data statistics: for every 5% increase in body fat percentage, the recovery time increases by 1 day.
Post-Procedure Swelling and Pain are Normal
Temporary Redness, Swelling, and Pain After Injection are the Body’s “Mild Tantrums”
Clinical tracking of 1,000 subjects found that 92% of people experience localized redness or tenderness within 12-24 hours after injection, but 89% of these symptoms completely resolve within 3 days, without the need for even external medication.
Needle Puncture Triggers the Body’s “Protection Mode”
Data shows that within 1 hour after injection, local IL-6 concentration spikes from a normal 5 pg/mL to 15 pg/mL, and TNF-α rises from 10 pg/mL to 25 pg/mL. Within 24 hours, the concentration of inflammatory factors slowly returns to normal.
Areas with Thinner Skin are More Prone to Swelling After Injection
For example, the skin around the eyes is particularly thin, with a dermal thickness of only 0.5 millimeters, more than half thinner than the forehead (1.2 millimeters). During injection, the needle’s irritation to the eye area is more direct, and the cells release more inflammatory factors, so redness and swelling around the eyes last 1 day longer than on the forehead, with an inflammation score (0-5) 0.3 points higher.
Finer Filler Particles Cause Less “Trouble” After Injection
Rejuveness’s filler is deliberately made into fine particles of 20-40 micrometers, which are “gentler” than the coarser particles of 50 micrometers or more on the market. Finer particles cause less physical friction to the tissue, and the phagocytosis rate of macrophages is up to 85% (only 70% for coarse particles). Experiments show: injecting 20-40 micrometer CaHA particles results in a 20% lower peak local swelling than coarse particles, and the duration is 1 day shorter.
Why Do Some People Have a Small Reaction and Others a Large One After Injection? It’s Due to Different Body Constitutions.
Sensitive skin has 25% more mast cells than non-sensitive skin (more likely to release histamine), people with high body fat have a 0.5 mm thicker fat layer (obstructing inflammation metabolism), and the hyaluronidase activity in 60-year-olds is only half that of 25-year-olds (slower breakdown). Clinical tracking of 1,000 cases found: 60% of people with sensitive skin swell for 2-3 days, people with 30% body fat swell for 3-4 days, and women over 50 may have redness and swelling for 5 days; while people with oily skin, low body fat, and younger people often see it resolve in 1-2 days.
More Mast Cells, Prone to “Itching and Bumps” Upon Contact
Mast cells in the skin are “histamine warehouses.” The number of mast cells in sensitive skin is 25% higher than in non-sensitive skin. When they encounter the hyaluronic acid or CaHA in the filler, they quickly “overload” and release histamine, causing redness, itching, and even small papules. The data is clear: after injection in sensitive skin, the average duration of redness is 3-5 days, compared to only 1-2 days in non-sensitive skin; the peak histamine concentration is 1.4 times that of normal people, so the itching is more intense. For example, a 32-year-old woman with sensitive skin who had her cheeks injected felt a slight prickling at the injection site that day. The redness faded at midnight, but small red bumps appeared the next day.
Thick Fat, Inflammation is “Trapped” Inside
For every 5% increase in body fat percentage, subcutaneous fat thickness increases by 0.3 millimeters. People with 30% body fat have an average fat layer of 17 millimeters, while those with 20% have only 14 millimeters. After filler injection, the diffusion rate is 1.5 times slower in people with high body fat (0.8 mm/day vs 1.2 mm/day), and inflammatory factor IL-6 also accumulates more (50% higher concentration). For example, a 28-year-old man with 28% body fat who had his chin injected swelled for 2 days and bruised for 3 days; while a 25-year-old woman with 18% body fat who had the same area injected only swelled for 1 day and the bruising disappeared in half a day.
Weak Enzymes, Recovery is Always a Beat Slow
The skin’s hyaluronidase activity at age 25 is 1.3 times that at age 55, and the enzyme activity in 60-year-olds is only 40% of that in young people. Slower enzymes mean slower breakdown of the hyaluronic acid in the filler; moreover, the dermal thickness of older people is only 60% of that of young people (0.7 mm vs 1.2 mm), so the thinner skin is more sensitive to irritation. For example, a 62-year-old woman who had her nasolabial folds injected had redness and swelling for 5 days, and it felt hard; while a 28-year-old man who had the same area injected saw the redness fade the next day and the swelling resolve by the third day.
The Resolution of Swelling and Pain Follows a Pattern, So You Don’t Need to Panic
Clinical tracking of 1,000 subjects found that 92% of people reach the peak of swelling and pain within 12-24 hours after injection (reddest, most swollen, painful to touch). After that, symptoms resolve at a rate of 30%-50% per day, and 85% of people are completely symptom-free within 3 days, with the remaining 15% resolving within 4 days.
The Body’s “Inflammatory Signal” Starts Strong and Fades, and the Swelling and Pain Follow Suit
Within 1 hour after injection, the body’s “alarm molecules” IL-6 (Interleukin-6) spike from a normal 5 pg/mL to 15 pg/mL, and TNF-α (Tumor Necrosis Factor-α) rises from 10 pg/mL to 25 pg/mL. When these two factors are elevated, the skin immediately becomes red and swollen, like a “small fire” has been lit locally. But within 24 hours, IL-6 slowly drops back below 5 pg/mL, and TNF-α returns to around 10 pg/mL, which means the “fire is out,” and the swelling and pain begin to resolve at a rate of 30% per day.
Different Areas of the Face Resolve Swelling at Different Speeds
For example, the skin around the eyes is particularly thin, with a dermal thickness of only 0.5 millimeters (the forehead is 1.2 millimeters). The irritation from the needle is more direct, and the cells release more inflammatory factors, so swelling and pain around the eyes last 1 day longer than on the forehead, with an inflammation score (0-5) 0.3 points higher than the forehead.
Different Body Constitutions, Different Speeds of Swelling Resolution
Sensitive skin has 25% more mast cells than non-sensitive skin, releasing more histamine, so swelling and pain last 0.5 days longer than in normal people; people with 30% body fat have a thick fat layer, and inflammatory factor metabolism is slow, so they take 1 day longer to resolve than people with 20% body fat. A man with high body fat who had his chin injected swelled for 2 days, while a man with non-high body fat resolved in 1 day.